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KMID : 0895419990090020066
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Journal of Korean Society of Occupational and Enviromental Hygiene
1999 Volume.9 No. 2 p.66 ~ p.78
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Study on Inhalation Toxicity of Iso - butylalcohol Using SD Rats
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한정희/Han, Jeong Hee
이성배/이용묵/하창수/정재황/윤효인/정용현/Lee, Sung bae/Lee, Yong Mook/Ha, Chang Soo/Jeong, Jae Hwang/Yun, Hyo In/Chung, Yong Hyun
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Abstract
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The purpose of this study was to investigate the toxic effects of iso-butylalcohol on Sprague-Dawley (SD) rats which were treated 0, 333, 1,000 and 3,000 ppm for 6 hours a day, 5 days a week for 13 weeks by inhalation.
Iso-butylalcohol did not induce any abnormal change in the viewpoint of clinical signs, feed consumption, ophthalmic test, urinalysis, hematology and blood biochemistry during and at the termination of the inhalation toxicity test. We did not find any abnormal findings in the gross and microscopic observations due to the inhalation of
iso-butylalcohol. There was no alteration in relative organ weight owing to the inhalation of the iso-butylalcohol.
In conclusion, concentration was 3,000 ppm in rats under the inhalation of 6 hours a day, 5 days a week for 13 weeks. Iso-butylalcohol did not show any change in the clinical signs, feed consumption, ophthalmic test, urinalysis, hematology and blood biochemistry, together with no alteration in the gross and pathological findings.
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